2005: ABC proteins and antibiotic drug resistance: is it all about transport?

2005-10-27 12:41:49 AM
1: Biochem Soc Trans. 2005 Oct;33(Pt 5):1000-2. Related Articles, Links
ABC proteins and antibiotic drug resistance: is it all about transport?
Kerr ID, Reynolds ED, Cove JH.
School of Biomedical Sciences, University of Nottingham, Queen's
Medical Centre, Nottingham NG7 2UH, U.K.
The precise mechanism of antibiotic-resistance-conferring ABC
(ATP-binding-cassette) proteins (termed NBD(2)) remains open to debate.
Currently, two hypotheses are recognized. In one, the NBD(2) proteins
are envisaged to act at the ribosome to impair antibiotic access to the
target site on the 23 S rRNA. In the other, NBD(2) proteins are
believed to act as the components of ATP driven efflux pumps by
associating with membrane spanning proteins capable of binding and
transporting antibiotics. Pertinent data in support of these two
hypotheses are discussed in this paper.
PMID: 16246031 [PubMed - in process]
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